|
KMID : 0363320070280010124
|
|
Journal of Korean Oriental Internal Medicine
2007 Volume.28 No. 1 p.124 ~ p.132
|
|
|
Effects of Hyunsamkabhangbang on the Hyperthyroidism Induced by Sodium Levothyroxine in Rats
|
|
Chang Sun-Kyu
Cho Chung-Sik
Kim Chul-Jung
|
|
|
Abstract
|
|
|
Objective : This study was to elucidate the effects of Hyunsamkabhangbang (HSK) on the hyperthyroidism induced by sodium levothyroxine.
Method : Sprague-Dawley rats were separated into five groups. Except the normal group, the other four groups were treated with sodium levothyroxine 160{mu}g/kg/day for 5 days by oral administration. Among the four groups, all except one (as control) were treated with various concentrations of HSK (0.5, 1.0, 2.0 g/kg/days) for 3 days separately. T3-uptake, T3, T4, TSH, total cholesterol, free fatty acid, {beta}-lipoprotein, glucose, ALP, AST, ALT change in the serum and body weight of rats were measured after medication of solid extract of HSK.
Results : HSK decreased significantly serum T3, T4, T3-uptake, ALP, free fatty acid and glucose level in a dose-dependent manner compared with control. HSK increased significantly serum TSH and total cholesterol level and body weight in a dose-dependent manner compared with control. HSK also increased serum {beta}-lipoprotein level compared with control, but not statistically meaningfully. HSK increased significantly serum AST and ALT level compared with control, but relationship to hyperthyroidism is not found.
Conclusions : From these results, it could be concluded that HSK lowers excess thyroid hormone and increased metabolism, resulting in improvement of hyperthyroid state.
|
|
|
KEYWORD
|
|
|
Hyperthyroidism, HYUNSAMKABHANGBANG(HSK), Sodium levothyroxine, T3, T4, TSH
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|